Publications

2010
Tischner D, Woess C, Ottina E, Villunger A.
Bcl-2-regulated cell death signalling in the prevention of autoimmunity.
Cell Death Dis. 2010 Jun 3;1:e48. doi: 10.1038/cddis.2010.27. Review.
PMID: 21364654

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH.
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
Nat Genet. 2011 Jan;43(1):17-9. doi:10.1038/ng.728. Epub 2010 Dec 12.
PMID: 21151127

Wiegers GJ, Kaufmann M, Tischner D, Villunger A.
Shaping the T-cell repertoire: a matter of life and death.
Immunol Cell Biol. 2011 Jan;89(1):33-9. doi: 10.1038/icb.2010.127. Epub 2010 Nov 9. Review.
PMID: 21060321

Labi V, Villunger A.
PUMA-mediated tumor suppression: A tale of two stories.
Cell Cycle. 2010 Nov 1;9(21):4269-75. Epub 2010 Nov 15.
PMID: 20980816

Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A.
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis.
Cell Death Differ. 2010 Nov;17(11):1672-83. doi:10.1038/cdd.2010.97. Epub 2010 Aug 13.
PMID: 20706276

Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A.
Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation.
Genes Dev. 2010 Aug 1;24(15):1602-7. doi:10.1101/gad.1940210.
PMID: 20679395

Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L, Cosialls AM, de Frias M, Campàs C, González-Barca E, Alonso E, Labi V, Viollet B, Benito A, Pons G, Villunger A, Gil J.
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
Blood. 2010 Oct 21;116(16):3023-32. doi:10.1182/blood-2010-05-283960. Epub 2010 Jul 27.
PMID: 20664053

Villunger A. Only the strong survive.
Immunity. 2010 Jun 25;32(6):729-31. doi: 10.1016/j.immuni.2010.06.010.
PMID: 20620937

Krumschnabel G, Ebner HL, Hess MW, Villunger A.
Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium.
Aquat Toxicol. 2010 Aug 1;99(1):73-85. doi: 10.1016/j.aquatox.2010.04.005. Epub 2010 Apr 10.
PMID: 20435356

Hagenbuchner J, Ausserlechner MJ, Porto V, David R, Meister B, Bodner M, Villunger A, Geiger K, Obexer P.
The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression.
J Biol Chem. 2010 Mar 5;285(10):6904-12. doi: 10.1074/jbc.M109.038331. Epub 2010 Jan 5.
PMID: 20051518

Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, Tzankov A, Villunger A.
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood. 2010 Feb 4;115(5):995-1005. doi: 10.1182/blood-2009-03-212670. Epub 2009 Dec 3.
PMID: 19965635

Parajuli N, Müller-Holzner E, Böck G, Werner ER, Villunger A, Doppler W.
Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice.
Int J Cancer. 2010 Feb 15;126(4):896-908. doi: 10.1002/ijc.24805.
PMID: 19653277

2009
Krumschnabel G, Manzl C, Villunger A.
Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase.
Oncogene. 2009 Sep 3;28(35):3093-6. doi: 10.1038/onc.2009.173. Epub 2009 Jul 6. Review.
PMID: 19581929

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.
Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043. Epub 2009 May 19.
PMID: 19454543

Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A.
Caspase-2 activation in the absence of PIDDosome formation.
J Cell Biol. 2009 Apr 20;185(2):291-303. doi: 10.1083/jcb.200811105. Epub 2009 Apr 13.
PMID: 19364921

Frenzel A, Grespi F, Chmelewskij W, Villunger A.
Bcl2 family proteins in carcinogenesis and the treatment of cancer.
Apoptosis. 2009 Apr;14(4):584-96. doi: 10.1007/s10495-008-0300-z.
PMID: 19156528

Nordigården A, Kraft M, Eliasson P, Labi V, Lam EW, Villunger A, Jönsson JI.
BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Blood. 2009 Mar 5;113(10):2302-11. doi: 10.1182/blood-2008-07-167023. Epub 2008 Dec 8.
PMID: 19064725

Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A.
The enigma of caspase-2: the laymen's view.
Cell Death Differ. 2009 Feb;16(2):195-207. doi: 10.1038/cdd.2008.170. Epub 2008 Nov 21. Review.
PMID: 19023332

2008
Ploner C, Kofler R, Villunger A.
Noxa: at the tip of the balance between life and death.
Oncogene. 2008 Dec;27 Suppl 1:S84-92. doi: 10.1038/onc.2009.46. Review.
PMID: 19641509

Piñon JD, Labi V, Egle A, Villunger A.
Bim and Bmf in tissue homeostasis and malignant disease.
Oncogene. 2008 Dec;27 Suppl 1:S41-52. doi:10.1038/onc.2009.42. Review.
PMID: 19641506

Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G.
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.
Immunity. 2008 Aug 15;29(2):205-16. doi: 10.1016/j.immuni.2008.06.008.
PMID: 18701084

Labi V, Grespi F, Baumgartner F, Villunger A.
Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
Cell Death Differ. 2008 Jun;15(6):977-87. doi: 10.1038/cdd.2008.37. Epub 2008 Mar 28. Review.
PMID: 18369371

Labi V, Erlacher M, Kiessling S, Manzl C, Frenzel A, O'Reilly L, Strasser A, Villunger A.
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development.
J Exp Med. 2008 Mar 17;205(3):641-55. doi: 10.1084/jem.20071658. Epub 2008 Feb 25.
PMID: 18299399

Michalak EM, Villunger A, Adams JM, Strasser A.
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.
Cell Death Differ. 2008 Jun;15(6):1019-29. doi: 10.1038/cdd.2008.16. Epub 2008 Feb 8.
PMID: 18259198