Publications

2013
Fava LL, Haschka MD, Villunger A.
Bim vanishes in the light of a mitotic Aurora.
Cell Death Differ. 2013 Dec;20(12):1597-8. doi: 10.1038/cdd.2013.140.
PMID: 24212928

Wensveen FM, Geest CR, Libregts SFWM, Derks IAM, Ekert PG, Labi V, Villunger A, Nolte MA, Eldering E.
BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis.
Apoptosis. 2013 Nov;18(11):1306-1318. doi:10.1007/s10495-013-0890-y.
PMID: 23975731

Hannesdóttir L, Tymoszuk P, Parajuli N, Wasmer MH, Philipp S, Daschil N, Datta S, Koller JB, Tripp CH, Stoitzner P, Müller-Holzner E, Wiegers GJ, Sexl V, Villunger A, Doppler W.
Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response.
Eur J Immunol. 2013 Oct;43(10):2718-29. doi:10.1002/eji.201242505. Epub 2013 Jul 11.
PMID: 23843024

Ottina E, Pellegrini M, Villunger A.
Guarding effector T-cell survival: all for one, Mcl-1 for all?
Cell Death Differ. 2013 Aug;20(8):969-71. doi:10.1038/cdd.2013.55.
PMID: 23832147

Egle A, Asslaber D, Villunger A, Pinon-Hofbauer J.
Bid-ding for mercy: twisted killer in action.
Cell Death Differ. 2013 Jul;20(7):847-9. doi:10.1038/cdd.2013.40.
PMID: 23749178

Farrés J, Martín-Caballero J, Martínez C, Lozano JJ, Llacuna L, Ampurdanés C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yélamos J.
Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.
Blood. 2013 Jul 4;122(1):44-54. doi: 10.1182/blood-2012-12-472845. Epub 2013 May 15.
PMID: 23678004

González-Gironès DM, Moncunill-Massaguer C, Iglesias-Serret D, Cosialls AM, Pérez-Perarnau A, Palmeri CM, Rubio-Patiño C, Villunger A, Pons G, Gil J.
AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts.
Apoptosis. 2013 Aug;18(8):1008-16. doi: 10.1007/s10495-013-0850-6.
PMID: 23605481

Manzl C, Baumgartner F, Peintner L, Schuler F, Villunger A.
Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines.
Methods. 2013 Jun 1;61(2):130-7. doi:10.1016/j.ymeth.2013.02.012. Epub 2013 Feb 27.
PMID: 23454286

Fava LL, Bock FJ, Geley S, Villunger A.
Caspase-2 at a glance. J Cell Sci. 2012 Dec 15;125(Pt 24):5911-5. doi: 10.1242/jcs.115105. Review.
PMID: 23447670

Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A.
Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.
Cell Death Differ. 2013 Apr;20(4):546-57. doi: 10.1038/cdd.2012.152. Epub 2012 Dec 14.
PMID: 23238565

Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M.
Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf.
EMBO Mol Med. 2013 Jan;5(1):122-36. doi: 10.1002/emmm.201201235. Epub 2012 Nov 24.
PMID: 23180554

Tischner D, Villunger A. Bcl-G acquitted of murder!
Cell Death Dis. 2012 Oct 11;3:e405. doi: 10.1038/cddis.2012.147.
PMID: 23059824

Tischner D, Manzl C, Soratroi C, Villunger A, Krumschnabel G.
Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members.
Apoptosis. 2012 Nov;17(11):1197-1209. doi: 10.1007/s10495-012-0756-8.
PMID: 22971741

Montanez E, Karaköse E, Tischner D, Villunger A, Fässler R.
PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm.
J Cell Sci. 2012 Nov 1;125(Pt 21):5233-40. doi:10.1242/jcs.112029. Epub 2012 Sep 3.
PMID: 22946061

Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A.
PIDDosome-independent tumor suppression by Caspase-2.
Cell Death Differ. 2012 Oct;19(10):1722-32. doi: 10.1038/cdd.2012.54. Epub 2012 May 18.
PMID: 22595758

Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, Reichardt HM, Villunger A, Herold MJ.
Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood. 2012 Jun 21;119(25):6032-42. doi: 10.1182/blood-2011-12-399089. Epub 2012 May 11.
PMID: 22581448

Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM.
Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
Biochem J. 2012 Jun 15;444(3):591-9. doi: 10.1042/BJ20111588.
PMID: 22515271

Brunner S, Herndler-Brandstetter D, Arnold CR, Wiegers GJ, Villunger A, Hackl M, Grillari J, Moreno-Villanueva M, Bürkle A, Grubeck-Loebenstein B.
Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death.
Aging Cell. 2012 Aug;11(4):579-87. doi:10.1111/j.1474-9726.2012.00819.x. Epub 2012 Apr 18.
PMID: 22435726

Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A.
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene. 2013 Jan 31;32(5):621-30. doi:10.1038/onc.2012.78. Epub 2012 Mar 19.
PMID: 22430207

2012
Ottina E, Tischner D, Herold MJ, Villunger A.
A1/Bfl-1 in leukocyte development and cell death.
Exp Cell Res. 2012 Jul 1;318(11):1291-303. doi:10.1016/j.yexcr.2012.01.021. Epub 2012 Feb 4. Review.
PMID: 22342458

Tischner D, Wiegers GJ, Fiegl H, Drach M, Villunger A.
Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells.
Cell Death Differ. 2012 Aug;19(8):1277-87. doi:10.1038/cdd.2012.7. Epub 2012 Feb 10.
PMID: 22322859

Bock FJ, Peintner L, Tanzer M, Manzl C, Villunger A.
P53-induced protein with a death domain (PIDD): master of puppets?
Oncogene. 2012 Nov 8;31(45):4733-9. doi: 10.1038/onc.2011.639. Epub 2012 Jan 23. Review.
PMID: 22266869

Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, Thuille N, Villunger A, Jan Wiegers G.
Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.
J Autoimmun. 2012 Feb;38(1):59-69. doi:10.1016/j.jaut.2011.12.008. Epub 2012 Jan 17.
PMID: 22257939

2011
Villunger A, Labi V, Bouillet P, Adams J, Strasser A.
Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?
Cell Death Differ. 2011 Oct;18(10):1545-6. doi:10.1038/cdd.2011.100.
PMID: 21909118

Baumgartner F, Villunger A.
Apoptosis: a barrier against cancer no more?
Hepatology. 2011 Oct;54(4):1121-4. doi: 10.1002/hep.24637.
PMID: 21898490

Schuster C, Berger A, Hoelzl MA, Putz EM, Frenzel A, Simma O, Moritz N, Hoelbl A, Kovacic B, Freissmuth M, Müller M, Villunger A, Müllauer L, Schmatz AI, Streubel B, Porpaczy E, Jäger U, Stoiber D, Sexl V.
The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.
Blood. 2011 Oct 27;118(17):4635-45. doi: 10.1182/blood-2010-10-313098. Epub 2011 Aug 30.
PMID: 21878673

Eitz Ferrer P, Potthoff S, Kirschnek S, Gasteiger G, Kastenmüller W, Ludwig H, Paschen SA, Villunger A, Sutter G, Drexler I, Häcker G.
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.
PLoS Pathog. 2011 Jun;7(6):e1002083. doi:10.1371/journal.ppat.1002083. Epub 2011 Jun 16.
PMID: 21698224

Hausmann M, Leucht K, Ploner C, Kiessling S, Villunger A, Becker H, Hofmann C, Falk W, Krebs M, Kellermeier S, Fried M, Schölmerich J, Obermeier F, Rogler G.
BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells.
J Biol Chem. 2011 Jul 29;286(30):26533-40. doi:10.1074/jbc.M111.265322. Epub 2011 Jun 14.
PMID: 21673109

Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Häcker H, Häcker G.
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa.
Cell Death Differ. 2011 Nov;18(11):1805-14. doi:10.1038/cdd.2011.69. Epub 2011 Jun 10.
PMID: 21660046

Bock FJ, Villunger A.
GSK3 TIPping off p53 to unleash PUMA.
Mol Cell. 2011 Jun 10;42(5):555-6. doi: 10.1016/j.molcel.2011.05.022.
PMID: 21658596

Grespi F, Ottina E, Yannoutsos N, Geley S, Villunger A.
Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.
PLoS One. 2011 Mar 21;6(3):e18051. doi:10.1371/journal.pone.0018051.
PMID: 21445314

Logette E, Schuepbach-Mallepell S, Eckert MJ, Leo XH, Jaccard B, Manzl C, Tardivel A, Villunger A, Quadroni M, Gaide O, Tschopp J.
PIDD orchestrates translesion DNA synthesis in response to UV irradiation.
Cell Death Differ. 2011 Jun;18(6):1036-45. doi: 10.1038/cdd.2011.19. Epub 2011 Mar 18.
PMID: 21415862

Wiegmans AP, Alsop AE, Bots M, Cluse LA, Williams SP, Banks KM, Ralli R, Scott CL, Frenzel A, Villunger A, Johnstone RW.
Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.
Cancer Res. 2011 May 15;71(10):3603-15. doi: 10.1158/0008-5472.CAN-10-3289. Epub 2011 Mar 11.
PMID: 21398407