Publications

2007

Kieran D, Woods I, Villunger A, Strasser A, Prehn JH.
Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice.
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20606-11. Epub 2007 Dec 11.
PMID: 18077368

Ploner C, Rainer J, Niederegger H, Eduardoff M, Villunger A, Geley S, Kofler R.
The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia.
Leukemia. 2008 Feb;22(2):370-7. Epub 2007 Nov 29.
PMID: 18046449

Ekoff M, Kaufmann T, Engström M, Motoyama N, Villunger A, Jönsson JI, Strasser A, Nilsson G.
The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells.
Blood. 2007 Nov 1;110(9):3209-17. Epub 2007 Jul 18.
PMID: 17634411

Olsson A, Manzl C, Strasser A, Villunger A.
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Cell Death Differ. 2007 Sep;14(9):1561-75. Epub 2007 Jul 13. Review.
PMID: 17627286

Hamrouni A, Olsson A, Wiegers GJ, Villunger A.
Impact of cellular lifespan on the T cell receptor repertoire.
Eur J Immunol. 2007 Jul;37(7):1978-85.
PMID: 17559169

Naik E, Michalak EM, Villunger A, Adams JM, Strasser A.
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.
J Cell Biol. 2007 Feb 12;176(4):415-24. Epub 2007 Feb 5.
PMID: 17283183

2006

Erlacher M, Labi V, Manzl C, Böck G, Tzankov A, Häcker G, Michalak E, Strasser A, Villunger A.
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.
J Exp Med. 2006 Dec 25;203(13):2939-51. Epub 2006 Dec 18.
PMID: 17178918

Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA.
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol. 2006 Dec 18;175(6):861-8.
PMID: 17178906

Häcker G, Bauer A, Villunger A.
Apoptosis in activated T cells: what are the triggers, and what the signal transducers?
Cell Cycle. 2006 Nov 1;5(21):2421-4. Epub 2006 Sep 12. Review.
PMID: 17102629

Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC, Kimura S, Ottmann OG, Druker BJ, Villunger A, Roberts AW, Strasser A.
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.
Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14907-12. Epub 2006 Sep 22.
PMID: 16997913

Concannon CG, Koehler BF, Reimertz C, Murphy BM, Bonner C, Thurow N, Ward MW, Villunger A, Strasser A, Kögel D, Prehn JH.
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.
Oncogene. 2007 Mar 15;26(12):1681-92. Epub 2006 Sep 18.
PMID: 16983338

Bauer A, Villunger A, Labi V, Fischer SF, Strasser A, Wagner H, Schmid RM, Häcker G.
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.
Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10979-84. Epub 2006 Jul 10.
PMID: 16832056

Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA.
BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.
J Neurosci. 2006 Jul 5;26(27):7257-64.
PMID: 16822983

You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, Villunger A, Mak TW.
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
J Exp Med. 2006 Jul 10;203(7):1657-63. Epub 2006 Jun 26.
PMID: 16801400

Kiessling S, Lutz-Nicoladoni C, Olsson A, Niederegger H, Baier G, Villunger A.
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha.
Cell Death Differ. 2007 Jan;14(1):186-9. Epub 2006 Jun 16.
PMID: 16778831.

Labi V, Erlacher M, Kiessling S, Villunger A.
BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.
Cell Death Differ. 2006 Aug;13(8):1325-38. Epub 2006 Apr 28. Review.
PMID: 16645634

2005

Adams JM, Huang DC, Strasser A, Willis S, Chen L, Wei A, van Delft M, Fletcher JI, Puthalakath H, Kuroda J, Michalak EM, Kelly PN, Bouillet P, Villunger A, O'Reilly L, Bath ML, Smith DP, Egle A, Harris AW, Hinds M, Colman P, Cory S.
Subversion of the Bcl-2 life/death switch in cancer development and therapy.
Cold Spring Harb Symp Quant Biol. 2005;70:469-77.
PMID: 16869785

Wong HK, Fricker M, Wyttenbach A, Villunger A, Michalak EM, Strasser A, Tolkovsky AM.
Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.
Mol Cell Biol. 2005 Oct;25(19):8732-47.
PMID: 16166651

Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A.
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.
Blood. 2005 Dec 15;106(13):4131-8. Epub 2005 Aug 23.
PMID: 16118324

Michalak E, Villunger A, Erlacher M, Strasser A.
Death squads enlisted by the tumour suppressor p53.
Biochem Biophys Res Commun. 2005 Jun 10;331(3):786-98. Review.
PMID: 15865934

Tan TT, Degenhardt K, Nelson DA, Beaudoin B, Nieves-Neira W, Bouillet P, Villunger A, Adams JM, White E.
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer Cell. 2005 Mar;7(3):227-38.
PMID: 15766661

Kirschnek S, Ying S, Fischer SF, Häcker H, Villunger A, Hochrein H, Häcker G.
Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim.
J Immunol. 2005 Jan 15;174(2):671-9.
PMID: 15634885

2004

Corazza N, Brumatti G, Jakob S, Villunger A, Brunner T.
TRAIL and thymocyte apoptosis: not so deadly?
Cell Death Differ. 2004 Dec;11 Suppl 2:S213-5.
PMID: 15514674

Heiser D, Labi V, Erlacher M, Villunger A.
The Bcl-2 protein family and its role in the development of neoplastic disease.
Exp Gerontol. 2004 Aug;39(8):1125-35. Review.
PMID: 15288687

Villunger A.
When cells die II: a comprehensive evaluation of apoptosis and programmed cell death.
Cell Death Differ. 2004 Jul;11(7):790-3.
PMID: 15205679

Villunger A, Marsden VS, Zhan Y, Erlacher M, Lew AM, Bouillet P, Berzins S, Godfrey DI, Heath WR, Strasser A.
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.
Proc Natl Acad Sci U S A. 2004 May 4;101(18):7052-7. Epub 2004 Apr 26.
PMID: 15118096

2003

Villunger A, Michalak EM, Coultas L, Müllauer F, Böck G, Ausserlechner MJ, Adams JM, Strasser A.
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.
Science. 2003 Nov 7;302(5647):1036-8. Epub 2003 Sep 18.
PMID: 14500851

Villunger A, Marsden VS, Strasser A.
Efficient T cell receptor-mediated apoptosis in nonobese diabetic mouse thymocytes.
Nat Immunol. 2003 Aug;4(8):717; author reply 718.
PMID: 12888786

Villunger A, Scott C, Bouillet P, Strasser A.
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival.
Blood. 2003 Mar 15;101(6):2393-400. Epub 2002 Nov 14.
PMID: 12433687

2001

Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A.
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.
Science. 2001 Sep 7;293(5536):1829-32.
PMID: 11546872

2000

Bauer B, Krumböck N, Ghaffari-Tabrizi N, Kampfer S, Villunger A, Wilda M, Hameister H, Utermann G, Leitges M, Uberall F, Baier G.
T cell expressed PKCtheta demonstrates cell-type selective function.
Eur J Immunol. 2000 Dec;30(12):3645-54.
PMID: 11169407

Villunger A, O'Reilly LA, Holler N, Adams J, Strasser A.
Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes.
J Exp Med. 2000 Sep 4;192(5):647-58.
PMID: 10974031

Spitaler M, Villunger A, Grunicke H, Uberall F.
Unique structural and functional properties of the ATP-binding domain of atypical protein kinase C-iota.
J Biol Chem. 2000 Oct 27;275(43):33289-96.
PMID: 10906326

Villunger A, Huang DC, Holler N, Tschopp J, Strasser A.
Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.
J Immunol. 2000 Aug 1;165(3):1337-43.
PMID: 10903735

1999

Huang DC, Hahne M, Schroeter M, Frei K, Fontana A, Villunger A, Newton K, Tschopp J, Strasser A.
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L).
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14871-6.
PMID: 10611305

Villunger A, Ghaffari-Tabrizi N, Tinhofer I, Krumböck N, Bauer B, Schneider T, Kasibhatla S, Greil R, Baier-Bitterlich G, Uberall F, Green DR, Baier G.
Synergistic action of protein kinase C theta and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells.
Eur J Immunol. 1999 Nov;29(11):3549-61.
PMID: 10556809

Villunger A, Strasser A.
The great escape: is immune evasion required for tumor progression?
Nat Med. 1999 Aug;5(8):874-5.
PMID: 10426306

Uberall F, Hellbert K, Kampfer S, Maly K, Villunger A, Spitaler M, Mwanjewe J, Baier-Bitterlich G, Baier G, Grunicke HH.
Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.
J Cell Biol. 1999 Feb 8;144(3):413-25.
PMID: 9971737

Ghaffari-Tabrizi N, Bauer B, Villunger A, Baier-Bitterlich G, Altman A, Utermann G, Uberall F, Baier G.
Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells.
Eur J Immunol. 1999 Jan;29(1):132-42.
PMID: 9933094

1998

Villunger A, Strasser A.
Does "death receptor" signaling play a role in tumorigenesis and cancer therapy?
Oncol Res. 1998;10(11-12):541-50. Review.
PMID: 10367935

Greil R, Egle A, Villunger A.
On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model.
Leuk Lymphoma. 1998 Nov;31(5-6):477-90. Review.
PMID: 9922038

Villunger A, Egle A, Kos M, Egle D, Tinhofer I, Henn T, Uberall F, Maly K, Greil R.
Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity.
Br J Haematol. 1998 Sep;102(4):1069-80.
PMID: 9734660

Kampfer S, Hellbert K, Villunger A, Doppler W, Baier G, Grunicke HH, Uberall F.
Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta.
EMBO J. 1998 Jul 15;17(14):4046-55.
PMID: 9670019

Tinhofer I, Marschitz I, Kos M, Henn T, Egle A, Villunger A, Greil R.
Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia.
Blood. 1998 Jun 1;91(11):4273-81.
PMID: 9596676

1997

Villunger A, Egle A, Kos M, Hartmann BL, Geley S, Kofler R, Greil R.
Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.
Cancer Res. 1997 Aug 15;57(16):3331-4.
PMID: 9269989

Villunger A, Egle A, Marschitz I, Kos M, Böck G, Ludwig H, Geley S, Kofler R, Greil R.
Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.
Blood. 1997 Jul 1;90(1):12-20.
PMID: 9207432

Egle A, Villunger A, Marschitz I, Kos M, Hittmair A, Lukas P, Grünewald K, Greil R.
Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status.
Br J Haematol. 1997 May;97(2):418-28.
PMID: 9163609

Geley S, Hartmann BL, Kapelari K, Egle A, Villunger A, Heidacher D, Greil R, Auer B, Kofler R.
The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells.
FEBS Lett. 1997 Jan 27;402(1):36-40.
PMID: 9013854

1996

Egle A, Villunger A, Kos M, Böck G, Gruber J, Auer B, Greil R.
Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2.
Eur J Immunol. 1996 Dec;26(12):3119-26.
PMID: 8977313

Gruber J, Geisen F, Sgonc R, Egle A, Villunger A, Boeck G, Konwalinka G, Greil R.
2',2'-Difluorodeoxycytidine (gemcitabine) induces apoptosis in myeloma cell lines resistant to steroids and 2-chlorodeoxyadenosine (2-CdA).
Stem Cells. 1996 May;14(3):351-62.
PMID: 8724701

Villunger A, Egle A, Kos M, Hittmair A, Maly K, Greil R.
Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies.
Int J Cancer. 1996 Feb 8;65(4):498-505.
PMID: 8621234

1991

Doppler W, Villunger A, Jennewein P, Brduscha K, Groner B, Ball RK.
Lactogenic hormone and cell type-specific control of the whey acidic protein gene promoter in transfected mouse cells.
Mol Endocrinol. 1991 Nov;5(11):1624-32.
PMID: 1685765